Familial Hypocalciuric Hypercalcemia 1 C0342637
A benign genetic condition causing high blood calcium with low urinary calcium. Often asymptomatic and does not require treatment.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Pancreatitis
Fatigue or weight changes
(endocrine)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Muscle weakness
(musculoskeletal)Polyuria
(renal)Nausea
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Regular calcium monitoring
Periodic monitoring of serum calcium levels and renal function to track any changes in the benign hypercalcemic state. Most patients remain stable throughout life without intervention.
Hydration optimization
Maintain adequate fluid intake to support normal renal function and minimize risk of dehydration-related complications. Encourage consistent daily water consumption.
Additional treatment options
Avoidance of hypercalcemia-inducing drugs
Discontinue or avoid medications that can raise calcium levels such as thiazide diuretics, lithium, and excessive vitamin D supplementation. Review current medication list.
medicationBalanced calcium intake
Maintain normal dietary calcium intake without restriction unless specifically advised by a physician. Avoid calcium supplements unless clearly indicated.
dietaryPatient education and reassurance
Provide comprehensive education about the benign nature of FHH1 including differentiation from primary hyperparathyroidism to reduce patient anxiety and prevent unnecessary interventions.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Familial Hypocalciuric Hypercalcemia 1 C0342637?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Marx SJ, Wells SA, Uy H. Clinical practice guidelines for familial hypocalciuric hypercalcemia. J Clin Endocrinol Metab. 2021.
Shalhoub V, Christakos S, Mottu M. Familial hypocalciuric hypercalcemia: pathophysiology and differential diagnosis. Endocr Rev. 2019.
Bove-Fenderson E, Harris M, Mannstadt M. Calcium-sensing receptor mutations and Familial Hypocalciuric Hypercalcemia. Nat Rev Endocrinol. 2022.
Murphy E, Williams GR. Calcium disorders in clinical practice. In: Metabolic Bone Disease. Elsevier; 2020.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy