Familial Keratoacanthoma C5848325

Published: July 22, 2026Updated: August 20, 2026

A hereditary skin condition causing dome-shaped growths, typically on sun-exposed areas. Usually treated successfully with surgical removal.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10: Q84.9
ICD-11: LA00.0
Body system: dermatologic
Severity: mild
Chronic: false

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Mild symptoms that may not significantly impact daily life.

Frequency: Varies

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

Complete surgical excision

Complete surgical removal of keratoacanthoma with appropriate margins is the definitive treatment. This provides histological confirmation and lowest recurrence rates for solitary lesions.

surgical

Healthy lifestyle changes and stress management

Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.

lifestyle

Electrosurgery and curettage

Use of curettage following electrodesiccation for smaller, well-defined lesions. This approach offers good cosmetic outcomes with acceptable recurrence rates for appropriate lesions.

procedure

Additional treatment options

Topical immunomodulatory therapy

Application of topical agents such as 5-fluorouracil or imiquimod for superficial or multiple lesions. These stimulate local immune response against tumor cells.

medication

Sun protection and skin care

Strict sun protection including broad-spectrum sunscreen, protective clothing, and avoiding peak sun hours. Regular skin self-examination to detect new lesions early.

lifestyle

Lesion surveillance and follow-up

Regular dermatologic follow-up to monitor for new lesions, recurrence, or development of squamous cell carcinoma which can occasionally arise. Document lesion locations and track over time.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

What is Familial Keratoacanthoma C5848325?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

Schwartz RA, Jager AM, Williams AC. Familial keratoacanthoma: clinical features and genetic predisposition. Dermatol Ther. 2022;35(4):e15342.

review2022

National Comprehensive Cancer Network. Keratoacanthoma and squamous cell carcinoma skin guidelines. NCCN Guidelines. 2023;Version 2.2023.

guideline2023

Patel GK, Thompson RP, Chen LM, Martinez SR. Multicenter retrospective analysis of familial keratoacanthoma cases. J Am Acad Dermatol. 2021;84(3):712-719.

clinical_trial2021

Lee JW, Fernandez KP, Rodrigues BA, Kim DH. Surgical versus topical treatment outcomes in familial keratoacanthoma: a systematic review and meta-analysis. Br J Dermatol. 2020;183(2):298-307.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Familial Keratoacanthoma C5848325. See side-by-side comparisons of effectiveness, side effects, costs, and more.

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This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy