Fanconi Anemia Complementation Group I C1836861
A rare Fanconi anemia type involving DNA repair defects. Leads to bone marrow failure, low blood counts, and increased cancer risk. Care includes monitoring, transfusions, and stem cell transplant evaluation.
Key facts at a glance
- ICD-10
- D61.03
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bone marrow failure
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Fatigue
(hematologic)Thumb abnormalities
(hematologic)Renal anomalies
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Hematopoietic Stem Cell Transplantation
Curative approach for bone marrow failure using chemotherapy and/or radiation followed by infusion of donor stem cells. This is the definitive treatment for severe aplastic anemia in Fanconi anemia patients.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Androgen Therapy
Synthetic androgens such as oxymetholone may stimulate bone marrow production and improve blood counts. This serves as a bridge therapy while awaiting transplantation or for patients without a suitable donor.
Additional treatment options
Cancer Surveillance Protocol
Regular screening including annual bone marrow exams, imaging studies, and tumor marker monitoring due to elevated solid tumor and hematologic malignancy risk in Fanconi anemia.
monitoringInfection Prevention Protocol
Meticulous hygiene practices, food safety measures, and avoidance of crowds during periods of neutropenia to prevent serious infections given compromised immune function.
lifestyleComprehensive Psychosocial Care
Counseling, support groups, and mental health services to address the chronic nature of the disease, treatment stress, and family adjustment challenges associated with Fanconi anemia.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Fanconi Anemia Complementation Group I C1836861?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy