Fanconi Anemia Complementation Group N C1835817
A rare genetic disorder affecting DNA repair, causing bone marrow failure and increased cancer risk. Management includes supportive care and stem cell transplant for eligible patients.
Key facts at a glance
- ICD-10
- D61.03
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Bone marrow failure (pancytopenia)
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Congenital skeletal anomalies (radial ray defects, thumb anomalies)
(hematologic)Renal malformations
(hematologic)Ocular abnormalities (microphthalmia, strabismus)
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Hematopoietic Stem Cell Transplantation
Curative treatment for bone marrow failure using chemotherapy and/or radiation followed by infusion of healthy stem cells from a matched donor. This procedure can restore normal blood cell production and is the only known cure for the hematological manifestations of Fanconi Anemia.
Androgen Therapy
Synthetic androgens such as oxymetholone can stimulate erythropoiesis and improve blood cell counts in patients with bone marrow failure. Response rates vary and treatment may lose efficacy over time, requiring monitoring for liver toxicity.
Additional treatment options
Comprehensive Cancer Surveillance Program
Regular screening including annual bone marrow exams, blood tests, and imaging for early detection of malignancies. Head and neck, gynecological, and gastrointestinal cancer screening is essential given increased cancer predisposition.
monitoringInfection Prevention Strategies
Implementation of rigorous hygiene practices, avoidance of crowds during illness outbreaks, and prompt evaluation of fevers. Patients with neutropenia are at high risk for serious bacterial and fungal infections requiring immediate medical attention.
lifestylePsychosocial Support Services
Counseling and mental health support to address chronic illness burden, body image concerns, family dynamics, and quality of life. Include support groups connecting patients with similar conditions for shared experiences and coping strategies.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Fanconi Anemia Complementation Group N C1835817?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy