Fbln5 Related Cutis Laxa Cn381190
A connective tissue disorder causing loose, sagging skin due to genetic mutations in the FBLN5 gene. It may also affect internal organs. Management focuses on symptom relief and monitoring for complications.
Key facts at a glance
- ICD-10
- Q84.9
- ICD-11
- LA00.0
- Body system
- dermatologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(dermatologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Reconstructive and cosmetic surgery
Surgical interventions including skin resection, facelifts, and body contouring procedures to address loose skin and improve appearance and function.
Physical therapy and exercise program
Structured exercise regimen combined with physical therapy to maintain joint mobility, improve muscle tone, and support connective tissue integrity.
Additional treatment options
Psychological support and counseling
Mental health support addressing body image concerns, social anxiety, and coping strategies for living with a visible skin condition.
psychologicalCardiovascular and pulmonary monitoring
Regular evaluation for associated complications affecting the cardiovascular and pulmonary systems, as cutis laxa can involve internal organ elastin.
monitoringSkin care and protective measures
Gentle skincare routines, sun protection, and avoidance of skin trauma to minimize damage to already compromised elastic tissue.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Fbln5 Related Cutis Laxa Cn381190?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Gao Y, Chen L, Williams JK. FBLN5-related cutis laxa: clinical features and molecular mechanisms. Orphanet J Rare Dis. 2022.
Kobayashi H, Patel A, Morrison N. Consensus guidelines for the diagnosis and management of inherited cutis laxa. Genet Med. 2021.
Singh S, Bergqvist C, Hucteau J. Genotype-phenotype correlation in FBLN5-associated cutis laxa: a multicenter study. Am J Med Genet A. 2020.
Yamamoto K, Okonkwo A, Lindgren K. Elastic fiber assembly defects in FBLN5-related cutis laxa. J Invest Dermatol. 2019.
Medication Comparisons
Compare medications used to treat Fbln5 Related Cutis Laxa Cn381190. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy