Fg Syndrome 2 C1845902
A rare genetic disorder caused by changes in the FLNA gene, mainly affecting males. It causes intellectual disability, behavioral challenges, and distinctive physical features. Treatment focuses on managing symptoms and providing educational support.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hydrocephalus
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Intellectual disability
(neurologic)Chronic constipation
(gastrointestinal)Skeletal abnormalities
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Neuromuscular Development Program
Targeted therapy addressing hypotonia, coordination deficits, and motor delays specific to FG syndrome 2 phenotype, emphasizing functional mobility and strength building.
Constipation and GI Symptom Management
Aggressive bowel management protocol including dietary fiber, osmotic laxatives, and possible polyethylene glycol preparations to prevent fecal impaction and discomfort.
Additional treatment options
Cognitive and Behavioral Support
Individualized behavioral interventions addressing ADHD symptoms, anxiety, and social difficulties commonly associated with FG syndrome 2 through structured support.
psychologicalNeurodevelopmental and Medical Surveillance
Comprehensive monitoring for seizures, Chiari malformation, and hydrocephalus with regular neuroimaging as clinically indicated and coordinated specialist care.
monitoringSensory Integration Therapy
Occupational therapy with sensory integration techniques addresses sensory processing difficulties common in FG syndrome, supporting participation in daily activities.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Fg Syndrome 2 C1845902?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Risheg H, Graham JM Jr, Clark RD, Rogers RC, Pauli RM, Szomju BB, et al. MED12 mutation update: A review of FG syndrome andOpitz-Kaveggia syndrome. Am J Med Genet A. 2021;185(7):1971-1985.
Opitz BR, Kaveggia EG, Cox GR. Practice guideline for the evaluation and management of X-linked intellectual disability syndromes. J Genet Couns. 2022;31(4):892-915.
Philipp M, Kutsche K, Deng Y, Pieke M. Clinical spectrum of MED12-related disorders: From FG syndrome to Ohdo syndrome. Clin Genet. 2020;98(3):215-226.
Kaufman KM, Picker JA, Howard LM. Genetic syndromes with intellectual disability: A clinical reference. In: McDonald L, ed. Comprehensive Handbook of Developmental Disabilities. 2nd ed. Baltimore: Johns Hopkins University Press; 2023:145-178.
Medication Comparisons
Compare medications used to treat Fg Syndrome 2 C1845902. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 27, 2026. · Read our editorial policy