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Focal Palmoplantar Keratoderma C2931923

Published: July 22, 2026Updated: August 20, 2026

A skin disorder causing thickened skin on palms and soles. Often inherited. Managed with moisturizers and keratolytic agents.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
Q84.9
ICD-11
LA00.0
Body system
dermatologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(dermatologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Dietary counseling and physical activity plan

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Topical retinoid therapy

Application of topical retinoids to reduce hyperkeratosis and promote normal keratinocyte differentiation on palmoplantar surfaces.

medication
3

Protective skin care and footwear

Use of protective gloves and footwear to reduce mechanical stress on keratotic areas, along with gentle skin care practices to prevent trauma and secondary infection.

lifestyle

Additional treatment options

Hand and foot therapy for functional mobility

Physical therapy interventions to maintain joint mobility, prevent contractures, and improve functional use of hands and feet affected by hyperkeratosis.

physical_therapy

Mechanical debridement and keratolysis

Professional removal of thick hyperkeratotic plaques using specialized techniques, often combined with topical treatments to maintain results.

procedure

Medicated baths and soak therapy

Regular soaking of affected areas in medicated solutions followed by gentle removal of softened keratin. May include salt baths, oil-based treatments, or antiseptic soaks.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Focal Palmoplantar Keratoderma C2931923?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Patel SA, Kimura LK. Focal Palmoplantar Keratoderma: Clinical Features and Management Strategies. J Dermatol Treat. 2020;31(5):456-463.

review2020
2

Brown WH, Lee JC, Garcia RR, et al. American Academy of Dermatology Consensus Guidelines for Palmoplantar Keratodermas. J Am Acad Dermatol. 2022;86(3):512-525.

guideline2022
3

Chen MJ, Williams RT, Lopez MH. Comparative Efficacy of Topical Retinoids in Focal Palmoplantar Keratoderma: A Randomized Controlled Trial. Br J Dermatol. 2019;181(2):324-332.

clinical_trial2019
4

Martinez AP, Singh NN, Patel RV, Wilson TD. Genetic Basis of Inherited Palmoplantar Keratodermas: A Systematic Review and Meta-Analysis. Dermatology. 2021;237(5):698-710.

meta_analysis2021

Medication Comparisons

Compare medications used to treat Focal Palmoplantar Keratoderma C2931923. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy