Focal Segmental Glomerulosclerosis 1 C4551527
A genetic kidney disease causing scarring of the kidney's filtering units, leading to protein loss in urine. It can run in families and may progress to kidney failure. Treatment focuses on controlling symptoms and slowing disease progression.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Proteinuria
Hypertension
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Edema
(cardiovascular)Hematuria
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Immunosuppressive therapy
Corticosteroids or other immunosuppressants to reduce proteinuria and achieve remission of nephrotic syndrome. Treatment typically starts with high-dose steroids and may transition to steroid-sparing agents.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
ACE inhibitors or ARBs
Renin-angiotensin system blockers that reduce proteinuria and slow disease progression by decreasing intraglomerular pressure. Often used as adjunctive therapy regardless of blood pressure status.
Additional treatment options
Sodium and protein restriction
Dietary modification limiting sodium intake to reduce edema and blood pressure, with moderate protein restriction to decrease proteinuria and lessen kidney burden.
dietaryWeight management and physical activity
Maintaining healthy weight and engaging in appropriate physical activity to support cardiovascular health and reduce disease burden on the kidneys.
lifestyleRegular renal function monitoring
Frequent laboratory assessment including serum creatinine, proteinuria quantification, lipid panels, and monitoring for steroid complications. Essential for treatment adjustment.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Focal Segmental Glomerulosclerosis 1 C4551527?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy