Focal Segmental Glomerulosclerosis 2 C1858915
A genetic form of kidney disease where certain gene variations increase susceptibility to scarring of kidney filters. It primarily affects kidney function and can lead to nephrotic syndrome. Management includes medications and monitoring for progression.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Renal insufficiency
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Edema
(renal)Hypoalbuminemia
(renal)Hyperlipidemia
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
High-dose corticosteroid therapy
Initial treatment with corticosteroids to induce remission of nephrotic syndrome. Response rates vary, and treatment course typically lasts several months with gradual tapering.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Calceneurim inhibitors
Calcineurin inhibitors such as cyclosporine or tacrolimus for steroid-resistant or dependent patients. These immunosuppressants target podocyte function and can induce remission.
Additional treatment options
ACE inhibitors or ARBs for renoprotection
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers provide renoprotection by reducing intraglomerular pressure and proteinuria, slowing disease progression.
medicationLow-sodium therapeutic diet
Strict sodium restriction to manage hypertension and fluid retention commonly seen in nephrotic syndrome. Often combined with fluid restriction during active disease.
dietaryComprehensive nephrology surveillance
Regular follow-up with nephrology including urine protein quantification, serum albumin, lipid panels, and assessment for treatment complications like diabetes or infections.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Focal Segmental Glomerulosclerosis 2 C1858915?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Focal Segmental Glomerulosclerosis 2 C1858915. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy