Focal Segmental Glomerulosclerosis 3 C4016880
A genetic kidney disorder causing progressive scarring of the glomeruli, the kidney's filtering structures. Patients typically experience proteinuria and may develop chronic kidney disease. Treatment aims to preserve kidney function and manage symptoms.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Nephrotic-range proteinuria
Thromboembolic complications
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Peripheral edema
(cardiovascular)Azotemia
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
High-dose corticosteroid therapy is typically initiated as first-line treatment for FSGS-3 to induce remission of proteinuria and preserve kidney function. Response rates vary among patients, and prolonged use requires careful monitoring for potential side effects.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
Calcineurin inhibitor therapy
Calcineurin inhibitors such as cyclosporine or tacrolimus may be used as first-line or second-line agents, particularly for steroid-resistant cases. These immunosuppressants help reduce proteinuria and stabilize kidney function.
Additional treatment options
RAAS blockade therapy
ACE inhibitors or angiotensin receptor blockers are used to reduce proteinuria and slow disease progression by decreasing intraglomerular pressure. These agents provide renoprotective benefits independent of blood pressure control.
medicationSodium-restricted diet
A low-sodium diet (typically less than 2,000-2,300 mg daily) helps manage fluid retention, reduces edema, and supports blood pressure control. Sodium restriction can enhance the effectiveness of antihypertensive medications.
dietaryDisease activity monitoring
Regular monitoring includes serial measurements of urine protein-to-creatinine ratio, serum albumin, and estimated glomerular filtration rate to assess treatment response and disease progression. Imaging may be used to evaluate kidney structure.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Focal Segmental Glomerulosclerosis 3 C4016880?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy