Focal Segmental Glomerulosclerosis 7 C4014925
A genetic form of focal segmental glomerulosclerosis where specific inherited changes predispose individuals to kidney filter damage. The condition varies in severity and may require long-term kidney care. Treatment is tailored to individual symptoms.
Key facts at a glance
- ICD-10
- Q63.9
- ICD-11
- LA00.0
- Body system
- renal
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Sudden severe flank pain
Changes in urination or swelling
(renal)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Frothy urine
(renal)Peripheral edema
(renal)Fatigue
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Corticosteroid therapy
High-dose corticosteroids such as prednisone are typically initiated as first-line therapy to reduce proteinuria and induce remission by suppressing the immune-mediated damage to glomerular podocytes.
Renal disease management
Active treatment with regular monitoring by a healthcare provider is recommended.
ACE inhibitor or ARB therapy
Angiotensin-converting enzyme inhibitors or angiotensin receptor blockers are used to reduce proteinuria and slow disease progression by decreasing intraglomerular pressure.
Additional treatment options
Sodium-restricted, moderate protein diet
Dietary modifications including reduced sodium intake and controlled protein consumption help manage fluid retention and reduce proteinuria while preserving kidney function.
dietaryCalcineurin inhibitor therapy
For steroid-resistant cases, calcineurin inhibitors like cyclosporine or tacrolimus may be prescribed to maintain remission and reduce proteinuria.
medicationBlood pressure and weight management
Maintaining optimal blood pressure control and healthy body weight through lifestyle modifications supports kidney function and enhances treatment efficacy.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Focal Segmental Glomerulosclerosis 7 C4014925?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Focal Segmental Glomerulosclerosis 7 C4014925. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy