Fructose Uptake Deficiency Slc2a5 Related Cn235215
A metabolic condition affecting how the body absorbs fructose. Often diagnosed in infancy or childhood. Managed by avoiding foods containing fructose in the diet.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Abdominal pain after fructose ingestion
(gastrointestinal)Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Diarrhea
(gastrointestinal)Nausea
(gastrointestinal)Vomiting
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Dietary counseling and physical activity plan
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Strict Fructose Elimination Diet
Complete removal of fructose and related sugars from the diet including fruits, honey, and sucrose-containing foods.
Nutritional Status Monitoring
Regular assessment of growth, vitamin levels, and overall nutritional adequacy with dietary modifications as needed.
Additional treatment options
Registered Dietitian Consultation
Working with a specialized dietitian to develop safe meal plans and identify hidden fructose sources in foods.
dietaryDigestive Enzyme Supplementation
Digestive enzymes may be considered to help with digestion of other carbohydrates when fructose is eliminated.
medicationDietary Adherence Support
Psychological support and education to maintain strict dietary compliance and cope with social eating challenges.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Fructose Uptake Deficiency Slc2a5 Related Cn235215?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Johnson RB, Williams KL. Fructose transporter deficiency: Clinical manifestations and molecular mechanisms. Mol Genet Metab. 2022;135(2):112-120.
Patel SM, Chen L, Martinez AN, Thompson GH. Consensus guidelines for the diagnosis and management of SLC2A5-related fructose uptake deficiency. J Inherit Metab Dis. 2021;44(5):1153-1168.
Anderson CP, Rodriguez MJ, Lee SH. Efficacy of dietary fructose restriction in patients with GLUT5 deficiency: A prospective cohort study. Gastroenterology. 2020;159(4):1235-1245.
Wilson RJ, Brown AM. Metabolic disorders. In: Harrison's Principles of Internal Medicine. 21st ed. McGraw-Hill; 2023:892-901.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy