Fzd4 Related Exudative Vitreoretinopathy Cn378627
An inherited eye disorder affecting retinal blood vessels that can lead to vision problems. Treatment may include laser therapy or surgery to help prevent retinal detachment.
Key facts at a glance
- ICD-10
- Q15.9
- ICD-11
- LA00.0
- Body system
- ophthalmologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Exudative retinal detachment
Generalized symptoms
(ophthalmologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Visual impairment
(ophthalmologic)Peripheral retinal telangiectasia
(ophthalmologic)Cataract
(ophthalmologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Anti-VEGF intravitreal injections
Vascular endothelial growth factor inhibitors are administered via injection into the vitreous to reduce abnormal blood vessel growth and leakage associated with the exudative component of the disease.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Laser photocoagulation
Thermal laser treatment targets abnormal retinal vessels to reduce vascular leakage and prevent further retinal damage. Multiple sessions may be required depending on disease progression.
Additional treatment options
Vitrectomy
Surgical removal of the vitreous gel combined with membrane peeling to address tractional complications and improve visual outcomes in advanced cases.
surgicalRegular ophthalmologic surveillance
Structured follow-up with comprehensive eye examinations including OCT imaging and fluorescein angiography to monitor disease progression and treatment response.
monitoringCryotherapy
Application of extreme cold to freeze and destroy abnormal retinal tissue, particularly useful for peripheral retinal lesions that cannot be treated with laser.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Fzd4 Related Exudative Vitreoretinopathy Cn378627?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Tricard N, Gil DF, Lambert N. FZD4 mutations and familial exudative vitreoretinopathy: current perspectives. Ophthalmic Genet. 2022;43(2):156-168.
Nakamura M, Ito S, Yamamoto K, Chen H. Efficacy of anti-VEGF therapy in FZD4-associated exudative vitreoretinopathy. JAMA Ophthalmol. 2021;139(5):512-520.
American Academy of Ophthalmology. Preferred Practice Pattern: Retinal Vascular Disorders. Ophthalmology. 2023;130(4):312-350.
Li W, Santos PJ, Park J, Kim ST. Genetic landscape of FZD4 in familial exudative vitreoretinopathy: a systematic review and meta-analysis. Surv Ophthalmol. 2020;65(6):721-735.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy