Gastric Diffuse Large B Cell Lymphoma C1335483
A cancer of the stomach arising from immune cells called lymphocytes. It typically affects adults and is treated with chemotherapy and sometimes radiation.
Key facts at a glance
- ICD-10
- C80.1
- ICD-11
- 2A00.0
- Body system
- oncologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal pain
Generalized symptoms
(oncologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Weight loss
(gastrointestinal)Nausea
(gastrointestinal)Anemia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Rituximab-based chemotherapy
Immunochemotherapy combining anti-CD20 monoclonal antibody with anthracycline-based chemotherapy regimens as first-line treatment for nodal and extranodal presentations.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Endoscopic biopsy and staging
Endoscopic evaluation with multiple biopsies for histopathological diagnosis, staging, and to assess depth of invasion. Helps guide treatment planning and assess HER2 status.
Additional treatment options
Targeted HER2 therapy
For HER2-positive tumors, addition of trastuzumab to standard chemotherapy improves outcomes. Treatment selection based on tumor biomarker status determined during staging.
medicationPsycho-oncology support
Psychological intervention addressing cancer-related anxiety, depression, and adjustment difficulties throughout treatment. May include individual counseling, support groups, and coping strategies.
psychologicalGastrectomy for localized disease
Surgical resection considered in limited-stage disease or when complications such as obstruction or perforation occur. Extent of resection depends on tumor location and staging.
surgicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Gastric Diffuse Large B Cell Lymphoma C1335483?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy