Giant Axonal Neuropathy 1 C1850386
Giant Axonal Neuropathy 1 is a rare inherited disorder that progressively damages nerve fibers throughout the body, causing weakness, sensory loss, and movement difficulties. It typically begins in childhood and worsens over time. Care focuses on managing complications and maintaining function.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Peripheral neuropathy
(neurologic)Gait disturbance
(neurologic)Loss of sensation in extremities
(neurologic)Difficulty with coordination
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Motor Therapy
Intensive physical therapy program focusing on maintaining muscle strength, preventing contractures, and preserving functional mobility. Includes stretching, strengthening, and gait training exercises.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Occupational Therapy
Occupational therapy to maintain independence in activities of daily living, address fine motor difficulties, and recommend adaptive equipment for daily functioning.
Additional treatment options
Neuropathic Pain Management
Pharmacological management of neuropathic pain using appropriate medications, which may include various classes of pain-modifying agents selected based on symptom profile.
medicationAssistive Device Provision
Provision and training with mobility aids such as walkers, wheelchairs, and orthotic devices to support independence and safety as motor function declines.
lifestyleNutritional Support Therapy
Dietary assessment and intervention to maintain adequate nutrition, prevent weight loss, and address swallowing difficulties that may develop with disease progression.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Giant Axonal Neuropathy 1 C1850386?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 25, 2026. · Read our editorial policy