Giant Axonal Neuropathy 2 C1864695
Giant Axonal Neuropathy 2 is a genetic condition similar to GAN1, causing progressive damage to peripheral and central nervous system nerves. It leads to muscle weakness, coordination problems, and sensory loss. Management involves supportive care and physical therapy.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Progressive peripheral neuropathy
(neurologic)Walking difficulties
(neurologic)Muscle weakness
(neurologic)Sensory ataxia
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Respiratory Function Surveillance
Regular monitoring of respiratory function including pulmonary function tests and sleep studies to detect respiratory muscle weakness and nocturnal hypoventilation early.
Respiratory Physical Therapy
Chest physiotherapy and breathing exercises to maintain lung capacity, clear secretions, and support respiratory muscle function in this neurodegenerative condition.
Additional treatment options
Physical and Occupational Therapy
Combined physical and occupational therapy approach to address progressive motor decline, maintain functional abilities, and adapt to changing capabilities.
physical_therapySymptomatic Pharmacological Management
Medication management for neuropathic symptoms, muscle spasms, and other neurological manifestations of giant axonal neuropathy.
medicationAquatic Therapy
Water-based therapy providing resistance training with reduced joint stress, offering an alternative exercise modality that can be beneficial for maintaining mobility.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Giant Axonal Neuropathy 2 C1864695?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Giant Axonal Neuropathy 2 C1864695. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy