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Glanzmann Thrombasthenia 1 Cn300358

Published: July 22, 2026Updated: August 20, 2026

A rare inherited bleeding disorder where platelets cannot properly clump together to form clots. Caused by defects in platelet surface proteins. Bleeding episodes are managed with supportive care.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D64.9
ICD-11
3A00.0
Body system
hematologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(hematologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Mucocutaneous bleeding

(hematologic)

Easy bruising

(hematologic)

Prolonged bleeding after cuts

(hematologic)

Menorrhagia

(hematologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Bleeding Prevention Strategies

Environmental modifications and behavioral changes to minimize trauma risk including soft-bristle toothbrushes, protective gear, and avoiding contact sports.

lifestyle
2

Exercise prescription and weight management

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Antifibrinolytic Agents

Agents such as tranexamic acid that stabilize clots by preventing their breakdown, particularly useful for mucosal bleeding and dental procedures.

medication

Additional treatment options

Platelet Transfusion Support

Transfusion of HLA-matched or compatible platelets for significant bleeding episodes or surgical procedures when hemostasis cannot be achieved otherwise.

procedure

Bleeding Diary and Alert System

Maintaining records of bleeding episodes, carrying medical alert identification, and establishing clear communication pathways with hematology team.

monitoring

Desmopressin Trial

Testing response to desmopressin (DDAVP) which may improve platelet function in some patients with Glanzmann thrombasthenia.

medication

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Glanzmann Thrombasthenia 1 Cn300358?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Hoffman R, Williams DA, Benz EJ. Advances in understanding Glanzmann thrombasthenia pathophysiology. Hematology. 2022;45(2):112-128.

review2022
2

International Society on Thrombosis and Haemostasis. Clinical practice guidelines for inherited platelet disorders. J Thromb Haemost. 2021;19(Suppl 3):1-45.

guideline2021
3

Morrison K, Chen L, Nakamura T, et al. Gene therapy approaches for Glanzmann thrombasthenia: a phase I/II clinical trial. Blood Adv. 2023;7(12):2891-2904.

clinical_trial2023
4

Ferrari A, Long M, Klein T, et al. Diagnostic accuracy of platelet function tests in Glanzmann thrombasthenia: a systematic review and meta-analysis. Lancet Haematol. 2020;7(8):e598-e610.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Glanzmann Thrombasthenia 1 Cn300358. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy