Glanzmann Thrombasthenia 2 C5543273
A variant of Glanzmann thrombasthenia with similar platelet aggregation defects. Like type 1, patients experience bleeding symptoms and require careful management during procedures.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Gingival bleeding
(hematologic)Petechiae
(hematologic)Hemarthrosis
(hematologic)Gastrointestinal bleeding
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Platelet Transfusion
Platelet transfusions provide functional platelets to temporarily correct the platelet aggregation defect in Glanzmann thrombasthenia. This is reserved for significant bleeding episodes or surgical prophylaxis.
Antifibrinolytic Agents
Antifibrinolytic medications like tranexamic acid help stabilize clots by preventing their breakdown. These are particularly useful for mucosal bleeding such as epistaxis or menorrhagia.
Additional treatment options
Bleeding Precaution Measures
Implementing environmental modifications and behavioral changes to minimize trauma risk, including using soft-bristle toothbrushes, avoiding contact sports, and wearing medical alert identification.
lifestyleRecombinant Activated Factor VII
Recombinant activated factor VII promotes hemostasis by activating the extrinsic pathway, providing an alternative to platelet transfusion in refractory bleeding situations.
procedureComprehensive Dental Management
Regular dental oversight with preventive care protocols including frequent cleanings, fluoride treatments, and coordinated hematology consultation for any dental procedures.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Glanzmann Thrombasthenia 2 C5543273?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Nurden AT, Pillois X, Wilcox DA. Advances in the understanding of the congenital thrombocytopenias and platelet disorders: Guidelines from the ISTH-SSC. J Thromb Haemost. 2022.
Alberio L, Clemetson KJ. All you never wanted to know about platelet GPIIb/IIIa. Blood Rev. 2021.
Di Paola J, Johnson J, Rivera C. Efficacy of recombinant factor VIIa in patients with Glanzmann thrombasthenia: A multicenter study. Blood Adv. 2019.
Ferrari B, Seligsohn U, Ingerslev J. Diagnosis and management of inherited platelet disorders: A systematic review. Haemophilia. 2020.
Medication Comparisons
Compare medications used to treat Glanzmann Thrombasthenia 2 C5543273. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy