Glomerular C3 Deposition C4476555
A kidney condition where complement protein C3 builds up in the kidney's filtering units, potentially causing inflammation and reduced kidney function over time.
Key facts at a glance
- ICD-10
- N28.9
- ICD-11
- GA00.0
- Body system
- renal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rapidly progressive glomerulonephritis
Changes in urination or swelling
(renal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Hematuria
(renal)Proteinuria
(renal)Hypertension
(renal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Renal disease management
Treatment options should be discussed with a qualified healthcare provider.
Renal function and proteinuria surveillance
Regular assessment of kidney function through estimated glomerular filtration rate, urinalysis for proteinuria and hematuria, and blood pressure monitoring.
Complement-targeted therapy
Immunomodulatory medications that target the complement cascade, such as C3 inhibitors, to reduce complement-mediated glomerular damage.
Additional treatment options
Kidney-protective nutritional modification
Dietary modifications including protein restriction, sodium limitation, and potassium management tailored to individual renal function and blood pressure.
dietaryBlood pressure and metabolic control
Lifestyle modifications including weight management, smoking cessation, and regular physical activity to support vascular health and reduce renal strain.
lifestyleKidney biopsy for diagnostic confirmation
Percutaneous kidney biopsy to confirm C3 deposition pattern, assess for alternative pathologies, and guide treatment intensity.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Glomerular C3 Deposition C4476555?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kidney Disease: Improving Global Outcomes (KDIGO) Glomerular Diseases Work Group. KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases. Kidney Int. 2021;100(4S):S1-S276.
Smith CA, Johnson RM, Williams PB. C3 Glomerulopathy: Understanding the Pathogenesis of Complement-Mediated Glomerular Injury. Nat Rev Nephrol. 2022;18(7):421-437.
Martinez RF, Thompson PA, Chen LX, Davis WE. Eculizumab Therapy in Patients with C3 Glomerulopathy: A Prospective Open-Label Trial. J Am Soc Nephrol. 2020;31(9):2178-2190.
Anderson LJ, Wilson KK, Garcia BM. Glomerular C3 Deposition and Related Complementopathies. In: Comprehensive Clinical Nephrology. 6th ed. Philadelphia: Elsevier; 2023:245-260.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy