Glucocorticoid Deficiency 1 C4049650
A disorder where the adrenal glands fail to produce enough cortisol, an essential stress hormone. It can affect children and adults, causing fatigue, low blood sugar, and salt craving. Treatment involves lifelong cortisol replacement therapy.
Key facts at a glance
- ICD-10
- E34.9
- ICD-11
- 5A00.0
- Body system
- endocrine
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(endocrine)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Endocrine management
Active treatment with regular monitoring by a healthcare provider is recommended.
Glucocorticoid replacement therapy
Lifelong hydrocortisone or equivalent glucocorticoid replacement using physiologic dosing schedules with stress dosing protocols for illness or surgery.
Mineralocorticoid replacement
Fludrocortisone supplementation for mineralocorticoid deficiency to maintain electrolyte balance, blood pressure, and fluid homeostasis.
Additional treatment options
Adrenal insufficiency monitoring
Regular endocrine follow-up with hormone level testing, electrolyte monitoring, and assessment of growth, development, and quality of life.
monitoringEmergency preparedness training
Patient and family education on adrenal crisis recognition, emergency injection protocols, and medical alert identification for stress situations.
lifestyleSodium and hydration management
Adequate dietary sodium intake and hydration to support mineralocorticoid function and prevent hyponatremia and hypotension.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Glucocorticoid Deficiency 1 C4049650?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy