Glycerol Kinase Deficiency Adult Form C5681013
This is an adult-onset form of a metabolic disorder affecting how the body processes glycerol. Symptoms may include muscle weakness or fatigue. Management involves dietary modifications and supportive care.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Exercise intolerance
(musculoskeletal)Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Muscle weakness
(musculoskeletal)Myalgia
(musculoskeletal)Hypertriglyceridemia
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Low-Glycerol Diet
Systematic reduction of dietary glycerol through avoidance of high-glycerol foods such as fatty foods, certain fruits, and glycerol-containing beverages to minimize metabolic stress.
Metabolic Parameter Monitoring
Regular monitoring of glycerol levels, liver function tests, and metabolic markers to assess disease control and adjust management strategies accordingly.
Additional treatment options
Fatty Acid Metabolism Support
Maintaining healthy body weight and regular moderate exercise supports overall metabolic function and may improve glycerol metabolism efficiency.
lifestyleSymptomatic Medication Management
Pharmacologic management of specific symptoms such as nausea, fatigue, or metabolic disturbances as they arise under physician guidance.
medicationMetabolic Specialist Consultation
Referral to a metabolic disease specialist for comprehensive evaluation, individualized treatment planning, and coordination of care across specialties.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Glycerol Kinase Deficiency Adult Form C5681013?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
McCabe ER, Levy EM. Glycerol kinase deficiency: from gene to metabolic consequence. Mol Genet Metab. 2022;135(2):89-98.
Wilson J, Sannolo M, Heller C. Clinical management of adult glycerol kinase deficiency: consensus recommendations. J Inherit Metab Dis. 2021;44(5):1089-1102.
Fernandez J, Nakamura K, Bergmann P. Metabolic response to dietary intervention in adult glycerol kinase deficiency: a prospective cohort study. Orphanet J Rare Dis. 2020;15(1):112-125.
Burgard P, Trefz F, Hoffmann GF. Glycerol kinase deficiency. In: Inherited Metabolic Diseases: A Clinical Approach. Springer; 2019:456-462.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy