Granulomatous Disease Chronic Autosomal Recessive 5 C5394542
An inherited immune disorder where white blood cells cannot kill certain bacteria and fungi, leading to recurrent infections. Lifelong management with preventive antibiotics is typically needed.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent pneumonia
(respiratory)Skin abscess
(integumentary)Hepatic abscess
(hepatobiliary)Osteomyelitis
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Prophylactic Antimicrobial Therapy
Continuous preventive antibiotics such as trimethoprim-sulfamethoxazole or itraconazole to reduce frequency and severity of bacterial and fungal infections.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunoglobulin Replacement Therapy
Regular intravenous or subcutaneous immunoglobulin infusions to provide passive immunity against common pathogens that patients cannot effectively combat.
Additional treatment options
Infection Surveillance Program
Regular clinical assessments and laboratory monitoring for early detection of infections and inflammatory complications including granuloma formation.
monitoringGranuloma Management Procedures
Surgical intervention for symptomatic granulomas causing obstruction or tissue damage, including drainage, resection, or corrective procedures.
surgicalInfection Prevention Practices
Rigorous hand hygiene, food safety measures, respiratory precautions, and avoidance of environmental sources of infection to minimize exposure risks.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Granulomatous Disease Chronic Autosomal Recessive 5 C5394542?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy