Hemochromatosis Type 2b C1865616
A rare genetic iron overload disorder caused by HAMP gene mutations, leading to severe iron accumulation in organs. Usually presents in youth and requires phlebotomy treatment.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Liver cirrhosis
Fatigue or weight changes
(metabolic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Diabetes mellitus
(endocrine)Fatigue
(general)Arthritis
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Therapeutic phlebotomy
Aggressive phlebotomy protocol to reduce iron overload, similar to type 2a. Initial intensive phase aims to deplete iron stores followed by lifelong maintenance sessions. Ferritin and transferrin saturation guide treatment frequency.
Endocrine and cardiac surveillance
Type 2b often presents with severe endocrine involvement including diabetes and hypogonadism. Regular endocrine panel testing, cardiac MRI for iron deposition, and glucose monitoring essential.
Additional treatment options
Iron chelation therapy
Pharmacological iron chelation for patients intolerant of phlebotomy or with severe iron overload affecting cardiac function. Chelating agents bind iron for urinary elimination and require regular monitoring.
medicationAlcohol avoidance
Complete avoidance of alcohol consumption essential as it accelerates hepatic iron absorption and increases liver damage risk. Patient education on alcohol content in medications and foods also important.
lifestyleIron absorption reduction diet
Low-iron diet emphasizing reduced intake of heme iron sources and avoidance of iron-fortified foods. Limiting vitamin C intake with meals reduces non-heme iron absorption.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hemochromatosis Type 2b C1865616?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy