Hemochromatosis Type 3 C1858664
Hemochromatosis Type 3 is a hereditary iron overload disorder caused by gene mutations affecting iron regulation. It can damage the liver, heart, and other organs. Treatment involves phlebotomy to lower iron levels.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Fatigue
(metabolic)Arthralgia
(metabolic)Diabetes mellitus
(metabolic)Liver cirrhosis
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Phlebotomy-based iron depletion
Therapeutic phlebotomy remains a cornerstone of treatment, though patients with TFR2-related hemochromatosis may require earlier or more intensive intervention compared to HFE-related disease.
Iron chelation therapy
Chelation therapy becomes particularly important when phlebotomy is insufficient or contraindicated, providing an alternative pathway for iron elimination in type 3 disease.
Additional treatment options
Hepatic evaluation program
Detailed liver assessment including elastography, biopsy when indicated, and serial monitoring for cirrhosis development and hepatocellular carcinoma risk.
monitoringCardiac iron assessment
Cardiac MRI with T2* imaging to detect and quantify myocardial iron deposition, with echocardiography and ECG surveillance for cardiomyopathy development.
monitoringTargeted nutritional counseling
Individualized dietary planning to minimize iron absorption including avoidance of red meat, shellfish, iron-fortified products, and vitamin C supplementation with meals.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hemochromatosis Type 3 C1858664?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bacon BR, Adams PC, Kowdley KV, Powell LW, Tavill AS. Diagnosis and management of hemochromatosis: 2011 practice guideline by the American Association for the Study of Liver Diseases. Hepatology. 2011.
Pietrangelo A. Hereditary hemochromatosis: new insights in pathogenesis and diagnosis. Arch Med Res. 2020.
Camaschella C, Roetto A, Calì A, et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet. 2000.
Ekanayake D, Rodd C, Miller C, Hershberger M, Cuellar N. Systematic review of genotype-phenotype correlations in hereditary hemochromatosis types 2, 3, and 4. Blood Rev. 2022.
Medication Comparisons
Compare medications used to treat Hemochromatosis Type 3 C1858664. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy