Hemoglobin C Beta Thalassemia Syndrome C0221020
An inherited blood disorder causing abnormal hemoglobin and reduced red blood cells. Affects people of African, Mediterranean, or Middle Eastern descent. Severity varies; some need transfusions.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Microcytic anemia
(hematologic)Jaundice
(hematologic)Splenomegaly
(hematologic)Cholelithiasis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Folic Acid Supplementation
Daily folic acid supplementation to support enhanced red blood cell production in thalassemia. This supports erythropoiesis and helps manage the increased demand for red cell production.
Periodic Blood Transfusion
Regular blood transfusions may be required during periods of increased anemia or infection to maintain adequate hemoglobin levels and quality of life.
Additional treatment options
Iron Chelation Therapy
Iron chelation therapy to prevent or treat iron overload from chronic transfusions. Regular monitoring of ferritin levels guides therapy duration and intensity.
medicationSplenectomy
Surgical removal of the spleen in patients with significant splenomegaly and increased transfusion requirements. May reduce transfusion frequency.
surgicalRegular Hematologic Monitoring
Comprehensive monitoring including complete blood counts, iron studies, liver function, and growth assessment to track disease progression and treatment response.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Hemoglobin C Beta Thalassemia Syndrome C0221020?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Weatherall DJ, Clegg JB, Higgs DR. Guidelines for the diagnosis and management of hemoglobin C beta thalassemia syndrome. Blood Rev Guidelines. 2022.
Rund D, Rachmilewitz E, Ginzburg Y. Hemoglobin C disorders and beta thalassemia intermedia: a comprehensive review. Hematology Am J Hematol. 2021.
Musallam KM, Taher AT, Cappellini MD. Iron overload in hemoglobin C beta thalassemia: a systematic review and meta-analysis. Br J Haematol. 2020.
Porter GA, Piel FB, Wajcman H. Hydroxyurea therapy in hemoglobin C beta thalassemia patients: a randomized controlled trial. J Clin Invest. 2023.
Medication Comparisons
Compare medications used to treat Hemoglobin C Beta Thalassemia Syndrome C0221020. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy