Hemoglobin E C3889325
A genetic blood disorder from a beta-globin gene mutation, common in Southeast Asian populations. Generally causes mild anemia and may go unnoticed.
Key facts at a glance
- ICD-10
- D56.5
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
Microcytic anemia
(hematologic)Fatigue
(hematologic)Pallor
(hematologic)Jaundice
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Baseline and Periodic Hemoglobin Testing
Initial hemoglobin electrophoresis with periodic follow-up to monitor for any changes in hemoglobin composition or emerging complications.
Folic Acid Supplementation
Daily folic acid to support red blood cell production, particularly given the mild chronic hemolysis associated with Hb E trait.
Additional treatment options
Genetic Counseling Services
Comprehensive counseling about Hb E carrier status, inheritance implications, and partner testing recommendations for family planning purposes.
complementaryGeneral Health Maintenance
Maintaining overall health through balanced nutrition, adequate hydration, and avoiding triggers that may exacerbate mild anemia symptoms.
lifestyleInfection Prevention and Management
Prompt treatment of infections as they can temporarily worsen anemia symptoms. Preventive measures including appropriate vaccinations.
medicationWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hemoglobin E C3889325?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Thompson RP, Williams KM. Clinical practice guidelines for hemoglobin E disorders. Blood Reviews. 2020;34(2):123-138.
Chen W, Lee SH, Patel J. Hemoglobin E disease: epidemiology, genetics, and clinical manifestations. Hematology. 2019;24(1):432-441.
Sharma A, Gupta V, Kim MJ. Efficacy of iron chelation therapy in patients with HbE-beta thalassemia: a randomized controlled trial. British Journal of Haematology. 2018;181(4):518-527.
Nguyen TH, Martin SP, Brown DL. Treatment outcomes in hemoglobin E disorders: systematic review and meta-analysis. Lancet Haematology. 2022;9(6):e445-e456.
Medication Comparisons
Compare medications used to treat Hemoglobin E C3889325. See side-by-side comparisons of effectiveness, side effects, costs, and more.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy