Hemoglobin S C3888302
A genetic condition combining features of sickle cell and hemoglobin C diseases, causing abnormal red blood cells. It primarily affects people of African and Mediterranean ancestry. Management focuses on relieving symptoms and preventing complications.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Acute chest syndrome
Ischemic stroke
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Vaso-occlusive pain crisis
(hematologic)Chronic hemolytic anemia
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Hydroxyurea Therapy
Hydroxyurea increases fetal hemoglobin production, reducing the frequency of painful crises and the need for transfusions. This disease-modifying treatment is standard for eligible patients.
Pharmacological management with first-line agents
Active treatment with regular monitoring by a healthcare provider is recommended.
Crisis Prevention and Hydration Management
Aggressive hydration, temperature regulation, and avoiding triggers such as extreme temperatures, high altitude, and dehydration. Patient education on recognizing early crisis symptoms is essential.
When to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hemoglobin S C3888302?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy