Hemolytic Anemia Due To A Disorder Of Glycolytic Enzymes C5681713
Red blood cells break down prematurely due to inherited defects in energy-producing enzymes. Can cause chronic anemia, jaundice, and fatigue. Treatment focuses on supportive care.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Jaundice
(hematologic)Splenomegaly
(hematologic)Biliary pain
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Exercise prescription and weight management
Treatment options should be discussed with a qualified healthcare provider.
Folic acid supplementation
Daily folic acid supplementation supports increased erythropoiesis in hemolytic anemia by providing essential substrate for red blood cell production.
Oxidative stress avoidance
Avoidance of oxidative triggers including certain medications, fava beans, and infections that can precipitate hemolytic crises in enzyme-deficient red cells.
Additional treatment options
Red blood cell transfusion
Transfusion therapy for severe symptomatic anemia or acute hemolytic crisis to maintain adequate oxygen-carrying capacity.
procedureSplenectomy
Surgical removal of the spleen in patients with significant splenic sequestration or inadequate response to conservative management.
surgicalRegular hematologic monitoring
Periodic blood count monitoring and hemolysis markers to assess disease severity and treatment response.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hemolytic Anemia Due To A Disorder Of Glycolytic Enzymes C5681713?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bianchi MG, Colombo NM, Rossi RA. Red cell glycolytic enzyme deficiencies: pathophysiology and clinical manifestations. Blood Rev. 2022.
American Society of Hematology. Evidence-based clinical practice guidelines for hereditary hemolytic anemias. Hematology Am Soc Hematol Educ Program. 2021.
Tanaka KR, Fujimoto S, Yamamoto H. Efficacy of red cell transfusion in pyruvate kinase deficiency: a multicenter study. Br J Haematol. 2020.
Van Wijk R, Bartelds A, Kootstra N. Molecular diagnosis of glycolytic enzyme defects: systematic review and meta-analysis. J Clin Pathol. 2019.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy