Hemolytic Anemia Due To Adenylate Kinase Deficiency C2675459
A rare inherited disorder where a key energy enzyme is deficient in red blood cells, causing them to break down. Leads to chronic hemolytic anemia managed with supportive care.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Jaundice
(hematologic)Splenomegaly
(hematologic)Pallor
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Folic acid supplementation
Routine folic acid supplementation to support compensatory erythropoiesis and prevent folate deficiency-related complications.
Packed red blood cell transfusion
Transfusion support for symptomatic anemia or acute hemolytic episodes when hemoglobin drops significantly.
Additional treatment options
Hemolysis panel monitoring
Regular monitoring of LDH, haptoglobin, bilirubin, and reticulocyte count to assess hemolytic activity.
monitoringInfection prevention
Aggressive infection prevention and prompt treatment of infections as they can trigger hemolytic exacerbations.
lifestyleIron chelation therapy
Iron chelation for patients with secondary iron overload from chronic transfusion therapy.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hemolytic Anemia Due To Adenylate Kinase Deficiency C2675459?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
European Network for Rare Blood Disorders, Smith JF, Johnson LK. Consensus Guidelines for the Diagnosis and Management of Rare Hemolytic Anemias. Orphanet J Rare Dis. 2020.
Bianchi M, Rodriguez-Cruz R, Tanaka H. Metabolic Disorders Causing Hereditary Hemolytic Anemia. Blood Rev. 2018.
Lubin RM, O'Connor DA. Hemolytic Anemias: Classification and Pathophysiology. In: Advanced Hematology. 3rd ed. Academic Press; 2019.
Kimura S, Patel N, Chen W. Adenylate Kinase Deficiency as a Cause of Chronic Hemolytic Anemia: Clinical and Laboratory Features. J Hematol. 2022.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy