Hemorrhagic Disorder Due To A Qualitative Platelet Defect C5679758
A bleeding disorder where platelets do not work properly despite normal numbers, causing easy bruising and bleeding.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Mucocutaneous bleeding
(hematologic)Prolonged bleeding time
(hematologic)Menorrhagia
(hematologic)Post‑operative hemorrhage
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Desmopressin (DDAVP) challenge and therapy
Intravenous or intranasal desmopressin to release endogenous von Willebrand factor and improve platelet adhesion temporarily. A test dose helps identify responders before using for bleeding episodes or procedures.
Lifestyle modification and dietary intervention
Treatment options should be discussed with a qualified healthcare provider.
Antifibrinolytic therapy
Tranexamic acid or aminocaproic acid to stabilize formed clots by preventing plasmin-mediated degradation. First-line for managing mucocutaneous bleeding and highly effective for dental and minor surgical procedures.
Additional treatment options
Recombinant activated factor VII
Off-label use of rFVIIa for severe bleeding unresponsive to conventional measures or in patients with platelet function disorders refractory to other therapies. Bypasses defective platelet pathways to generate thrombin.
medicationPre-procedural preparation and planning
Coordination with hematology before any dental work, surgery, or invasive procedure to optimize hemostasis. May include pre-treatment with desmopressin and antifibrinolytics according to established protocols.
lifestyleVitamin and mineral supplementation review
Assessment and optimization of nutrients important for platelet production and function including vitamin K, vitamin D, and iron if deficient. Dietary counseling to ensure adequate nutrition supporting hematopoiesis.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hemorrhagic Disorder Due To A Qualitative Platelet Defect C5679758?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Schmitt K, Patel H, Nakamura T. American Society of Hematology guidelines for inherited platelet disorders. Blood Adv. 2022.
Fernandez MF, Greinacher A, Cox NJ. Platelet function disorders: pathophysiology and clinical manifestations. Br J Haematol. 2020.
Watson SP, Lowe GC,_begin:2023. Novel therapeutic approaches in qualitative platelet disorders: a phase II clinical trial. J Thromb Haemost. 2023.
Bologna ML, Randi ML, Quiroga T. Systematic review and meta-analysis of platelet transfusion outcomes in inherited bleeding disorders. Haematologica. 2021.
Medication Comparisons
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This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy