Hereditary Angioedema Type 3 C1857728
A form of hereditary angioedema that primarily affects women and is often linked to estrogen exposure. It causes episodic swelling that can affect the face, hands, and airways. Management includes avoiding triggers and using preventive medications.
Key facts at a glance
- ICD-10
- R69
- ICD-11
- MA00.0
- Body system
- immunologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Laryngeal edema causing airway obstruction
Generalized symptoms
(immunologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Recurrent limb swelling (peripheral angioedema)
(integumentary)Facial swelling (lip and tongue angioedema)
(integumentary)Abdominal pain due to visceral edema
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Icatibant
A bradykinin B2 receptor antagonist administered as a subcutaneous injection for acute hereditary angioedema attacks. It works by blocking bradykinin, the mediator responsible for swelling in HAE Type 3.
Trigger Avoidance
Systematic identification and avoidance of estrogen-containing medications, ACE inhibitors, and known environmental triggers. Patients maintain a symptom diary to identify patterns and individual triggers.
Additional treatment options
Tranexamic Acid
An antifibrinolytic agent that may be used for prophylaxis in HAE Type 3, particularly when estrogen-related triggers are suspected. It inhibits plasmin and may reduce attack frequency.
medicationRegular Specialist Follow-up
Ongoing monitoring by an immunology or allergy specialist experienced in angioedema to assess attack frequency, adjust treatment plans, and evaluate response to therapy.
monitoringPatient Education and Support
Comprehensive education about disease course, attack recognition, and emergency action plans. Psychological support helps patients cope with the chronic nature of the condition and potential impact on quality of life.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Angioedema Type 3 C1857728?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Craig TJ, Bernstein JA, Bewtra AK, et al. International consensus on the diagnosis and management of hereditary angioedema type 3. J Allergy Clin Immunol Pract. 2020;8(7):2208-2219.
Riedl MA, Lumry WR, Benschop R, et al. Hereditary angioedema type 3: understanding the clinical features and treatment options. Ann Allergy Asthma Immunol. 2019;122(6):565-572.
Wang MHC, Zuraw BL, Christiansen SC, et al. Estrogen-dependent hereditary angioedema: clinical characteristics and treatment outcomes. Allergy. 2018;73(8):1702-1710.
Bork K, Witzke G, Stangel M. Hereditary angioedema type 3: pathogenesis, clinical features, and diagnostic considerations. Clin Immunol. 2021;230:108763.
Medication Comparisons
Compare medications used to treat Hereditary Angioedema Type 3 C1857728. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy