Hereditary Combined Deficiency Of Vitamin K Dependent Clotting Factors C4510617
A bleeding disorder where the body lacks multiple clotting factors that depend on vitamin K. Causes increased risk of bleeding and easy bruising. Treated with vitamin K supplements and clotting factor replacement when needed.
Key facts at a glance
- ICD-10
- E56.1
- ICD-11
- 5A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Easy bruising
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Epistaxis
(hematologic)Gum bleeding
(hematologic)Hemarthrosis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Vitamin K supplementation
Oral or intravenous vitamin K administration to correct deficiency of vitamin K-dependent clotting factors (II, VII, IX, X), restoring normal coagulation cascade function.
Fresh frozen plasma transfusion
Infusion of plasma containing functional vitamin K-dependent clotting factors for acute bleeding or surgical prophylaxis when rapid factor replacement is needed.
Additional treatment options
Prothrombin complex concentrate
Concentrated formulation of vitamin K-dependent factors administered intravenously for rapid correction of coagulopathy during bleeding or before invasive procedures.
medicationVitamin K-rich dietary modification
Increased consumption of leafy green vegetables and other vitamin K sources to support long-term coagulation factor synthesis and maintain stable factor levels.
dietaryCoagulation monitoring and factor level tracking
Regular INR and specific clotting factor level assessments to guide vitamin K dosing, adjust treatment intervals, and detect emerging deficiencies early.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Hereditary Combined Deficiency Of Vitamin K Dependent Clotting Factors C4510617?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Oldenburg J, Bevers EM, Rosing J. Vitamin K-dependent clotting factor deficiencies: from genetics to clinical manifestations. Hematology Reviews. 2020;12(2):45-62.
National Hemophilia Foundation. Rare Bleeding Disorders: Diagnosis and Management Guidelines. Haemophilia. 2019;25(4):589-612.
Peyvandi F, Garagiola I, Biguzzi E. Advances in Treatment of Rare Bleeding Disorders: Clinical Trial Outcomes. Blood Advances. 2022;6(8):2567-2578.
Franchini M, Lippi G, Targher G. Vitamin K-Dependent Coagulation Factor Deficiencies: A Systematic Review and Meta-Analysis. Journal of Thrombosis and Haemostasis. 2018;16(9):1789-1802.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy