Hereditary Factor I Deficiency Disease C0019250
A rare inherited bleeding disorder caused by deficiency of fibrinogen, affecting both males and females. Treatment involves fibrinogen replacement therapy or plasma to prevent and control bleeding.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Mucosal bleeding
(hematologic)Easy bruising
(hematologic)Umbilical cord bleeding in newborns
(hematologic)Joint hemorrhage (hemarthrosis)
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Combination drug regimen with regular assessment
Active treatment with regular monitoring by a healthcare provider is recommended.
Fibrinogen concentrate replacement
Purified fibrinogen protein administered intravenously to replace deficient clotting factor, restoring normal hemostasis. This is the preferred replacement therapy offering precise dosing with reduced infection risk.
Cryoprecipitate transfusion
Blood product containing concentrated fibrinogen and other clotting factors transfused to control bleeding episodes when purified concentrates are unavailable. Requires blood typing and thawing time before administration.
Additional treatment options
Antifibrinolytic agents
Oral or intravenous medications that prevent clot breakdown by inhibiting plasmin, providing additional hemostatic support especially for mucosal bleeding or during surgical/dental procedures.
medicationTrauma prevention and activity modification
Comprehensive lifestyle modifications including avoiding contact sports, using protective gear, and making home safety modifications to minimize bleeding risk from injury throughout daily activities.
lifestyleVitamin K and nutrient optimization
Ensuring adequate vitamin K intake through leafy green vegetables and supplements supports overall coagulation cascade function, complementing factor replacement therapy.
dietaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hereditary Factor I Deficiency Disease C0019250?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Hereditary Factor I Deficiency Disease C0019250. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy