Hereditary Spastic Paraplegia 6 C1838192
An inherited neurological disorder causing progressive spasticity and weakness in the legs. Both males and females can be affected. Management focuses on physical therapy, medications, and maintaining mobility.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Lower limb spasticity
(neurologic)Gait disturbance
(neurologic)Urinary incontinence
(genitourinary)Pes cavus
(musculoskeletal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Comprehensive Motor Rehabilitation
Ongoing physical therapy focusing on lower extremity flexibility, strength training, and gait retraining to maximize functional independence.
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Baclofen-Based Spasticity Control
Oral baclofen therapy to reduce muscle tone abnormalities and improve walking efficiency. May be combined with physical therapy for enhanced outcomes.
When to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 6 C1838192?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding RM, Blackstone K. Hereditary Spastic Paraplegia 6: Genetic Mechanisms and Clinical Management. Neurologist. 2022;28(4):215-224.
International Hereditary Spastic Paraplegia Study Group. Clinical Practice Guidelines for Diagnosis and Management of Hereditary Spastic Paraplegias. Eur J Neurol. 2021;18(6):789-801.
Martinez JR, Chen S, Williams P, Kim H. Safety and Efficacy of Novel Therapeutic Agent in Hereditary Spastic Paraplegia: A Prospective Cohort Study. Mov Disord. 2023;38(2):234-242.
Patel V, Singh R, Lee J, Anderson K. Treatment Outcomes in Hereditary Spastic Paraplegia: A Systematic Review and Meta-Analysis. Lancet Neurol. 2023;22(5):412-425.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy