Hereditary Spastic Paraplegia 64 C3810289
A genetic disorder causing progressive leg stiffness and weakness due to nerve pathway degeneration. Typically begins in childhood or early adulthood. Physical therapy and medications help manage spasticity and maintain mobility.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Developmental delay
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive lower limb stiffness
(neurologic)Increased muscle tone in legs
(neurologic)Upper limb involvement
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Long-term Physical Therapy Protocol
Ongoing physical therapy emphasizing daily home exercises, regular therapist-guided sessions, and progressive training to maintain function. Focuses on preventing contractures, improving balance, and maximizing independence.
First-line Oral Antispasmodic Therapy
Oral muscle relaxant medications as initial pharmacological treatment for spasticity management. Started at conservative doses with gradual adjustment based on clinical response and tolerability.
Additional treatment options
Intrathecal Drug Delivery System
Surgically implanted pump system for continuous intrathecal delivery of antispasmodic medications. Considered for patients with severe spasticity unresponsive to oral therapy or those with intolerable systemic side effects.
surgicalActivity Modification and Energy Conservation
Education on activity pacing, ergonomic modifications, and energy conservation techniques to manage fatigue while maintaining meaningful daily activities and social participation.
lifestyleHydrotherapy and Aquatic Exercise
Water-based exercise programs utilizing buoyancy to reduce joint stress while allowing effective strengthening and stretching. Warm water additionally provides muscle relaxation benefits.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 64 C3810289?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Blackstone C, O'Kane R, Reid E. Hereditary spastic paraplegias: cellular functions and therapeutic targets. Nat Rev Neurosci. 2018;19(5):295-316.
Shetty J, McKenna F, Bainbridge J, et al. Consensus guidelines on the diagnosis, management, and genetic testing for hereditary spastic paraplegia. Neurology. 2021;97(4):184-197.
Kushing K, Lewin R, McDermott C. Gene-based therapies for hereditary spastic paraplegia: current approaches and future directions. Orphanet J Rare Dis. 2020;15(1):235-248.
Druzin M, Kurz J, O'Connor J, et al. Diagnostic criteria and classification of hereditary spastic paraplegia: a systematic review and meta-analysis. J Neurol Sci. 2019;405:68-81.
Medication Comparisons
Compare medications used to treat Hereditary Spastic Paraplegia 64 C3810289. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy