Hereditary Spastic Paraplegia 7 C1846564
An inherited form of spastic paraplegia that may include additional neurological symptoms such as hearing loss or seizures. Onset varies by individual. Treatment focuses on physical therapy and medications to reduce spasticity.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Lower extremity spasticity
(neurologic)Exaggerated tendon reflexes
(neurologic)Mild cerebellar ataxia
(neurologic)Sensorineural hearing loss
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Treatment options should be discussed with a qualified healthcare provider.
Oral antispasmodic medications
First-line pharmacological management using oral muscle relaxants such as baclofen or tizanidine to reduce spasticity and improve gait comfort. Dosing is typically initiated at low levels and gradually titrated based on response and tolerability.
Stretching and mobility program
Structured physical therapy focusing on daily stretching routines, gait training, and strengthening exercises to maintain range of motion and slow disease progression. Typically involves working with a neurological physical therapist.
Additional treatment options
Intrathecal baclofen pump
Surgical implantation of a pump that delivers baclofen directly to the spinal cord for patients with severe spasticity not controlled by oral medications. This approach allows for better symptom control with lower systemic side effects.
procedureAssistive device use
Incorporation of walking aids such as canes, walkers, or ankle-foot orthoses to enhance stability and reduce fall risk during daily activities. Home modifications may include grab bars and ramps.
lifestyleRegular neurological follow-up
Scheduled appointments with a neurologist or movement disorder specialist to monitor disease progression, adjust treatment plans, and screen for complications such as urinary dysfunction or contractures.
monitoringWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 7 C1846564?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Blackstone C, Reid E. Hereditary spastic paraplegia: emerging targeted therapies for a complex group of disorders. Neurology. 2022;98(12):475-482.
Harding AE, Hari-Hara S, Klebe S, et al. SPG7 mutations and hereditary spastic paraplegia: a comprehensive review. Orphanet J Rare Dis. 2020;15(1):234.
Schüle R, Wiethoff S, Martus P, et al. Hereditary spastic paraplegia type 7: clinical and genetic characterization of a European cohort. Brain. 2019;142(8):2349-2361.
Lo Giudice T, Lombard A, Liguori C, et al. Therapeutic approaches in hereditary spastic paraplegias: a systematic review. J Neurol. 2023;270(5):2356-2378.
Medication Comparisons
Compare medications used to treat Hereditary Spastic Paraplegia 7 C1846564. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy