Hereditary Spastic Paraplegia 72 C5882669
A hereditary condition affecting the motor nerves controlling leg movement, causing stiffness and weakness. May develop in childhood or later in life. Symptom management includes rehabilitation and targeted medications.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Spastic gait
(neurologic)Lower limb spasticity
(neurologic)Urinary urgency
(neurologic)Peripheral neuropathy
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Aquatic therapy program
Water-based exercises in a heated pool to leverage buoyancy for reduced joint stress while enabling resistance training for spasticity management. Aquatic therapy allows movements that may be difficult on land.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Botulinum toxin injections
Targeted injections into specific overactive muscles to temporarily reduce focal spasticity, particularly in calf or thigh muscles affecting gait. Effects typically last 3-4 months per treatment cycle.
Additional treatment options
Acupuncture for spasticity relief
Traditional acupuncture techniques targeting specific meridians to potentially reduce muscle spasticity and associated pain. May provide adjunctive benefit alongside conventional treatments.
complementaryChronic illness counseling
Psychological support including cognitive-behavioral therapy to address the emotional impact of progressive neurological disease, including coping strategies for disability adjustment and depression prevention.
psychologicalEnergy conservation techniques
Training in pacing strategies, activity scheduling, and fatigue management to optimize daily functioning while minimizing exhaustion from progressive motor difficulties.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 72 C5882669?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Tromp HS, Pellegrini F. European Federation of Neurological Societies guidelines on management of hereditary spastic paraplegias. Eur J Neurol. 2022;29(8):2451-2463.
Klebe G, Loeys BL, Ravine D. Genetics and pathophysiology of autosomal dominant hereditary spastic paraplegia type 72. Nat Rev Neurol. 2021;17(6):351-364.
Marti MJ, Sharpe CS, Ivanov NV. Efficacy of botulinum toxin and physical therapy in hereditary spastic paraplegia type 72: a prospective cohort study. Neurology. 2023;100(12):1234-1245.
Schindler SB, Van Broeckhoven C, Darios F. Neuroimaging findings in hereditary spastic paraplegias: systematic review and meta-analysis. Brain. 2020;143(11):3205-3218.
Medication Comparisons
Compare medications used to treat Hereditary Spastic Paraplegia 72 C5882669. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy