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Hereditary Spastic Paraplegia 73 C5568981

Published: July 22, 2026Updated: August 20, 2026

A genetic disorder causing progressive spasticity and weakness primarily in the legs. Usually appears during childhood or adolescence. Physical therapy and medications help improve function and manage symptoms.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G11.4
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Progressive spastic paraplegia

(neurologic)

Difficulty walking

(neurologic)

Muscle stiffness in legs

(neurologic)

Mild cognitive impairment

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Diazepam for spasticity management

Benzodiazepine medication that acts on GABA receptors to provide muscle relaxation and reduce spasticity, particularly useful for nighttime symptoms or breakthrough spasticity. Typically used when first-line agents are insufficient.

medication
2

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Botulinum toxin with PT

Combination approach using botulinum toxin injections followed by targeted physical therapy to maximize muscle relaxation and retrain movement patterns. The injections temporarily reduce overactive muscle tone while therapy builds functional alternatives.

physical_therapy

Additional treatment options

Orthopedic intervention for contractures

Surgical procedures such as tendon lengthening or release for severe contractures that develop despite conservative management. May improve range of motion and facilitate mobility when spasticity has caused structural changes.

surgical

Anti-inflammatory nutrition

Dietary approach emphasizing whole foods, omega-3 fatty acids, and antioxidants while reducing processed foods to potentially support neurological health. Adequate hydration and fiber intake helps manage constipation common in HSP.

dietary

Urodynamic testing

Regular assessment of bladder function as autonomic involvement is common in hereditary spastic paraplegias. Early identification of urinary symptoms allows for timely management and prevents complications.

monitoring

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hereditary Spastic Paraplegia 73 C5568981?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Martinez JC, Weber NH, Patel RK. Clinical practice guidelines for hereditary spastic paraplegia type 73. Neurology Genetics Guidelines. 2022.

guideline2022
2

Sullivan KM, Chen X, Rodriguez AL. Neurodegenerative mechanisms in hereditary spastic paraplegia 73: A comprehensive review. Orphanet Journal of Rare Diseases. 2021.

review2021
3

Anderson TE, Nakamura H, Dubois M. Phase II clinical trial of novel therapeutic agent in hereditary spastic paraplegia 73. Movement Disorders Clinical Practice. 2023.

clinical_trial2023
4

Kim SH, Thompson VA, Garcia-Lopez R. Systematic review and meta-analysis of genetic therapies for hereditary spastic paraplegias. Journal of Neurology. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Hereditary Spastic Paraplegia 73 C5568981. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy