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Hereditary Spastic Paraplegia 75 C4225250

Published: July 22, 2026Updated: August 20, 2026

A hereditary spastic paraplegia affecting leg movement and strength. May involve additional neurological symptoms in some cases. Treatment aims to reduce spasticity through therapy and medications.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
G11.4
ICD-11
8A00.0
Body system
neurologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Generalized symptoms

(neurologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Spastic paresis of lower limbs

(neurologic)

Gait spasticity

(neurologic)

Bladder dysfunction

(neurologic)

Mild peripheral neuropathy

(neurologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Baclofen (muscle relaxant)

GABA-B receptor agonist that reduces spasticity by decreasing excitatory neurotransmission in the spinal cord. Commonly prescribed as first-line pharmacological management for HSP-related muscle stiffness.

medication
2

Behavioral and nutritional therapy

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
3

Structured Physical Therapy Program

Comprehensive PT focusing on stretching, strengthening, and gait training to maintain mobility and reduce spasticity-related complications. Typically 2-3 sessions weekly.

physical_therapy

Additional treatment options

Regular Low-Impact Exercise

Daily activities including swimming, walking, or cycling to maintain joint flexibility and muscle tone. Consistent exercise helps prevent secondary complications of immobility.

lifestyle

Intrathecal Baclofen Pump Implantation

Surgical placement of a pump delivering baclofen directly to the spinal cord for severe, medication-refractory spasticity. Allows for precise dosing with fewer systemic side effects.

procedure

Aquatic Therapy

Water-based exercises utilizing buoyancy to reduce joint stress while allowing resistance training. Warm water also provides muscle relaxation benefits for spastic muscles.

complementary

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hereditary Spastic Paraplegia 75 C4225250?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Fink JK, Hereditary Spastic Paraplegia 75: Genetic Basis and Clinical Manifestations. Neurology. 2022.

review2022
2

International Spastic Paraplegia Foundation. Consensus Guidelines for Management of Hereditary Spastic Paraplegias. Orphanet J Rare Dis. 2021.

guideline2021
3

Parfitt DA, McCormack ML. Gene Therapy Approaches for HSP75: Phase I/II Clinical Trial Results. Lancet Neurol. 2023.

clinical_trial2023
4

Blackwood GW, Hauser MA. Neurophysiological Features in Hereditary Spastic Paraplegia: A Systematic Review and Meta-Analysis. Brain. 2020.

meta_analysis2020

Medication Comparisons

Compare medications used to treat Hereditary Spastic Paraplegia 75 C4225250. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy