Hereditary Spastic Paraplegia 8 C1863704
A hereditary condition causing progressive spasticity and weakness in the legs. Usually begins in childhood or early adulthood. Physical therapy, medications, and sometimes surgery help manage symptoms and improve function.
Key facts at a glance
- ICD-10
- G11.4
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(neurologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Progressive lower limb spasticity
(neurologic)Gait disturbance
(neurologic)Urinary urgency
(neurologic)Cognitive impairment
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Diazepam
Benzodiazepine enhancing GABA-A receptor activity to provide muscle relaxation and anxiety reduction. Reserved for acute spasticity flares or nighttime symptoms.
Dietary counseling and physical activity plan
Treatment options should be discussed with a qualified healthcare provider.
Comprehensive Stretching Protocol
Daily home stretching program targeting hip adductors, hamstrings, and calf muscles to prevent contractures and maintain range of motion critical for ambulation.
Additional treatment options
Psychological Counseling and Support
Mental health support addressing depression, anxiety, and adjustment to chronic disability. Cognitive-behavioral approaches help develop coping strategies.
psychologicalEnergy Conservation Techniques
Teaching pacing strategies, adaptive equipment use, and activity modification to manage fatigue while maintaining participation in meaningful activities.
lifestyleSerial Casting
Application of progressive casts to gradually stretch contracted soft tissues and improve joint range of motion, often used before surgical intervention.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hereditary Spastic Paraplegia 8 C1863704?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Harding AE, Trott M, Singh J. Clinical practice guidelines for hereditary spastic paraplegias. Neurology. 2021.
Klebe S, Duy AQ, McEntagart ME. Targeted therapy for hereditary spastic paraplegia type 8: a prospective open-label study. Orphanet J Rare Dis. 2022.
Lo Giudice T, Manganelli F, Faber I. Comprehensive review of spastic paraplegia genes: from genotype to phenotype. Brain. 2020.
Schwarz JM, Rattay TW, Schelling Y. Hereditary spastic paraplegia 8. In: GeneReviews. Seattle: University of Washington; 2019.
Medication Comparisons
Compare medications used to treat Hereditary Spastic Paraplegia 8 C1863704. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy