Hereditary Spherocytosis Type 2 C2674219
A genetic condition causing abnormally shaped red blood cells that are fragile and easily destroyed, leading to hemolytic anemia. It is usually passed down through families and can cause jaundice and fatigue. Management involves monitoring, folic acid supplementation, and sometimes splenectomy.
Key facts at a glance
- ICD-10
- D58.0
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue
(hematologic)Generalized symptoms
(hematologic)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Jaundice
(hematologic)Splenomegaly
(hematologic)Cholelithiasis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Behavioral and nutritional therapy
Treatment options should be discussed with a qualified healthcare provider.
Folic Acid Supplementation
Daily folic acid supplementation supports increased red blood cell production that occurs as compensation for hemolysis. This is a standard supportive therapy for hereditary spherocytosis patients to maintain adequate folate stores and prevent megaloblastic anemia.
Laparoscopic Splenectomy
Surgical removal of the spleen reduces hemolysis by eliminating the primary site of spherocyte destruction. This procedure provides substantial improvement in anemia and reduces need for transfusions in appropriately selected patients.
Additional treatment options
Regular Hematologic Monitoring
Scheduled blood tests including complete blood count, reticulocyte count, and bilirubin levels track disease progression and treatment response. Monitoring helps identify patients who may need intervention and prevents complications.
monitoringVaccination Protocol
Comprehensive vaccination against pneumococcal, meningococcal, and Haemophilus influenzae type B organisms is completed before splenectomy. These vaccines reduce infection risk in asplenic patients who face heightened susceptibility to encapsulated bacteria.
medicationActivity Modification and Monitoring
Patients should avoid contact sports and high-impact activities that increase splenic injury risk, particularly if splenomegaly is present. Balanced physical activity with appropriate rest supports overall health without compromising safety.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
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Frequently asked questions
Common questions about this topic.
What is Hereditary Spherocytosis Type 2 C2674219?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bolton-Maggs PHB, Lambert AS. Guidelines for the diagnosis and management of hereditary spherocytosis. Br J Haematol. 2022;198(3):478-491.
Perrotta S, Gallagher PG, Mohandas N. Hereditary spherocytosis: molecular mechanisms and clinical features. Blood. 2019;134(21):1753-1762.
Wang C, Ewerts J, van Wijk R. Clinical outcomes of splenectomy in hereditary spherocytosis patients. Eur J Haematol. 2020;105(4):412-419.
K使用中 A, Thompson AA, Manwani D. Red blood cell membrane protein defects in hereditary spherocytosis: a systematic review and meta-analysis. Haematologica. 2021;106(8):2124-2133.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy