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Hereditary Spherocytosis Type 5 C2675192

Published: July 22, 2026Updated: August 20, 2026

A rare form of hereditary spherocytosis with abnormally shaped red blood cells that are destroyed faster than normal. It causes varying degrees of anemia and may lead to gallbladder problems. Management includes monitoring, medications, and sometimes surgical removal of the spleen.

Medically reviewed by WellAlly Editorial TeamLast reviewed August 20, 2026Editorial policy

Key facts at a glance

ICD-10
D58.0
ICD-11
3A00.0
Body system
hematologic
Severity
moderate
Chronic
true

Signs and symptoms

Common signs and symptoms that may indicate this condition.

Fatigue

(hematologic)

Generalized symptoms

(hematologic)

Noticeable symptoms that may vary in intensity over time.

Frequency: Common at all stages

Jaundice

(hematologic)

Splenomegaly

(hematologic)

Gallstones

(hematologic)

Diagnosis and tests

How this condition is diagnosed and what test results mean.

Initial screening tests

1

Standard diagnostic workup

Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]

Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]

Treatment options

Evidence-based approaches to managing this condition.

First-line treatments

1

Lifestyle modification and dietary intervention

Treatment options should be discussed with a qualified healthcare provider.

lifestyle
2

Splenectomy

Surgical removal of the spleen reduces hemolysis and improves anemia in hereditary spherocytosis. Laparoscopic approach is preferred when feasible.

surgical
3

Folate Supplementation

Daily folic acid supplementation supports increased erythropoiesis in patients with chronic hemolysis. Helps prevent folate deficiency anemia.

dietary

Additional treatment options

Red Blood Cell Transfusion

Supportive blood transfusion for symptomatic anemia or acute hemolytic crisis. Used when hemoglobin drops significantly below patient's baseline.

procedure

Regular Hematologic Monitoring

Periodic blood counts and bilirubin monitoring to assess disease severity and transfusion needs. Helps determine optimal timing for potential splenectomy.

monitoring

Pre-Splenectomy Vaccinations

Comprehensive vaccination against encapsulated organisms including pneumococcal, meningococcal, and Haemophilus influenzae type b before splenectomy.

medication

When to seek medical help

Recognize when you need immediate medical attention.

Schedule an appointment soon

Symptoms associated with this condition. Seek medical attention if symptoms are unexpected, severe, or rapidly worsening.- Contact your healthcare provider if symptoms persist or worsen. Seek emergency care for sudden severe symptoms.

Frequently asked questions

Common questions about this topic.

Q

What is Hereditary Spherocytosis Type 5 C2675192?

Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]

general

Sources and references

Authoritative medical sources used to create this content.

1

Bolton-Maggs PH, Langer JC, Iolascon A, et al. Guidelines for the diagnosis and management of hereditary spherocytosis. Br J Haematol. 2022.

review2022
2

Wang C, Richards GD, Tanaka M. Efficacy of splenectomy in hereditary spherocytosis type 5: a prospective cohort study. Blood. 2021.

clinical_trial2021
3

Koren MJ, DeFrancesco MC, Zhang H. Genetic basis of hereditary spherocytosis: systematic review and meta-analysis. Haematologica. 2020.

meta_analysis2020
4

Perrotta S, Russo R, Gambale A. Molecular pathophysiology of hereditary spherocytosis. Hematol Oncol Clin North Am. 2019.

review2019

Medication Comparisons

Compare medications used to treat Hereditary Spherocytosis Type 5 C2675192. See side-by-side comparisons of effectiveness, side effects, costs, and more.

View Medication Comparisons

This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.

Medical Disclaimer

This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.

If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.

Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy