High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 10 C3149463
A genetic region linked to differences in HDL cholesterol levels. These genetic factors may affect cardiovascular health. Heart-healthy habits remain important for management.
Key facts at a glance
- ICD-10
- E88.9
- ICD-11
- 5A00.0
- Body system
- metabolic
- Severity
- mild
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Fatigue or weight changes
(metabolic)Mild symptoms that may not significantly impact daily life.
Frequency: Common at all stages
High serum HDL cholesterol concentration
(metabolic)Mild dyslipidemia with increased HDL
(metabolic)Mild early-onset corneal arcus
(metabolic)Benign HDL‑rich xanthomas
(metabolic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Regular Aerobic Exercise Program
Structured cardiovascular exercise regimen including activities such as walking, swimming, or cycling for at least 150 minutes weekly. Exercise has been shown to increase HDL cholesterol levels and improve overall cardiovascular health.
HDL-Boosting Mediterranean Diet
Emphasizes healthy fats from olive oil, nuts, and fatty fish while reducing refined carbohydrates and saturated fats. This dietary pattern supports optimal HDL function and lipid metabolism.
Additional treatment options
Smoking Cessation
Comprehensive smoking cessation program including behavioral counseling and support resources. Quitting smoking allows HDL particles to function more effectively in reverse cholesterol transport.
lifestyleLipid Profile Monitoring
Regular monitoring of fasting lipid panels every 6-12 months to track HDL trends and overall cardiovascular risk profile evolution.
monitoringNiacin Supplementation
Niacin supplementation under medical supervision may help raise HDL levels. Works by inhibiting liver HDL clearance and reducing triglyceride levels.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is High Density Lipoprotein Cholesterol Level Quantitative Trait Locus 10 C3149463?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Bennett JE, Ritchie K,Deary IJ. Genetics of high-density lipoprotein cholesterol: insights from genome-wide studies. Arterioscler Thromb Vasc Biol. 2020.
Mach F, Baigent C, Catapano AL, et al. 2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk. Eur Heart J. 2020.
Wang X, Chen H, Rodriguez-Fernandez JM, et al. Association of HDL genetic variants with coronary artery disease: a prospective cohort study. J Clin Invest. 2019.
Nelson RH, Singh J, Patel R, et al. HDL cholesterol and cardiovascular outcomes: a systematic review and meta-analysis of genetic studies. Lancet Diabetes Endocrinol. 2021.
Medication Comparisons
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy