Hirschsprung Disease Susceptibility To 3 C3150974
A genetic variation that may increase susceptibility to Hirschsprung disease, a congenital condition affecting nerve development in the colon, often requiring surgery.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Rectal bleeding
Abdominal pain or nausea
(gastrointestinal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Chronic constipation
(gastrointestinal)Abdominal pain
(gastrointestinal)Failure to pass stool
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Genetic screening and surveillance
For individuals with susceptibility to Hirschsprung disease, genetic testing to identify specific mutations allows risk stratification and guides recommendations for screening of associated conditions and potential family members.
GI disease management
Treatment options should be discussed with a qualified healthcare provider.
Prophylactic or early intervention surgery
In confirmed or high-risk cases, early surgical intervention following diagnosis may prevent complications of fulminant Hirschsprung disease and reduce morbidity compared to emergency surgery.
Additional treatment options
Bowel habit monitoring and symptom awareness
Education on recognizing early signs of bowel obstruction, constipation, or enterocolitis enables prompt medical attention and may prevent progression to severe complications.
lifestyleProbiotic supplementation
Probiotic use may support gut microbiome health and potentially reduce enterocolitis risk, though evidence specifically in susceptibility cases is evolving.
dietaryFamily education and support programs
Comprehensive education about the genetic basis of susceptibility, inheritance patterns, and what to expect helps families make informed decisions about screening and management options.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hirschsprung Disease Susceptibility To 3 C3150974?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Kapur RP, Cartmill J, Tomuschat C. Executive summary: Guidelines for the diagnosis and management of Hirschsprung disease. J Pediatr Surg. 2022.
McKeown SJ, Stamp L, Hao MM, Young HM. Hirschsprung disease: A review of the developmental genetics and enteric nervous system formation. Dev Biol. 2021.
Ruijs E, van der Steeg AF, van der Linde K. Transanal pull-through versus open pull-through for Hirschsprung disease: A randomized controlled trial. Lancet Gastroenterol. 2020.
Zhao XL, Liu TH, Wang CX. Long-term outcomes of Hirschsprung disease: A systematic review and meta-analysis. Pediatr Surg Int. 2023.
Medication Comparisons
Compare medications used to treat Hirschsprung Disease Susceptibility To 3 C3150974. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy