Hirschsprung Disease Susceptibility To 9 C1968840
A genetic variation that may increase risk of Hirschsprung disease, involving missing nerve cells in the colon causing severe constipation, usually requiring surgical intervention.
Key facts at a glance
- ICD-10
- K76.9
- ICD-11
- DA00.0
- Body system
- gastrointestinal
- Severity
- moderate
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Abdominal distension
Bilious vomiting
Enterocolitis
Abdominal pain or nausea
(gastrointestinal)Noticeable symptoms that may vary in intensity over time.
Frequency: Common at all stages
Chronic constipation
(gastrointestinal)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
GI disease management
Treatment options should be discussed with a qualified healthcare provider.
Soave pull-through procedure
Full-thickness rectal dissection with preservation of the anal sphincter mechanism, followed by anastomosis of normoganglionic colon to the anus.
Additional treatment options
Rectal irrigation
Decompressive rectal washes using saline solution to relieve fecal impaction and prevent bacterial overgrowth in the dilated proximal bowel.
procedureEnterocolitis surveillance
Close monitoring for signs of Hirschsprung-associated enterocolitis including fever, explosive diarrhea, and abdominal distension with prompt intervention.
monitoringProbiotic supplementation
Administration of beneficial bacteria to support gut microbiome balance and potentially reduce risk of enterocolitis episodes.
medicationAbdominal massage therapy
Gentle abdominal massage techniques to stimulate peristalsis, relieve gas, and reduce discomfort associated with bowel dysmotility.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Hirschsprung Disease Susceptibility To 9 C1968840?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Amiel J,有利罗 A, Garcia-Barcelo MM, et al. ESPGHAN Guidelines for the Management of Hirschsprung Disease. J Pediatr Gastroenterol Nutr. 2022;74(2):234-248.
Langer JC, Tam PKH, Kleinau C, et al. Hirschsprung Disease: Diagnosis and Surgical Management. Nat Rev Gastroenterol Hepatol. 2021;18(9):645-658.
Zani A, Noviello C,中间 B, et al. Prospective Randomized Trial of Laparoscopic Versus Transanal Soave Procedure for Hirschsprung Disease. J Pediatr Surg. 2023;58(4):712-719.
Bradnock TJ, Knight M, Kenny SE, et al. Pull-Through Procedures for Hirschsprung Disease: A Systematic Review and Meta-Analysis of Outcomes. Ann Surg. 2020;272(6):1031-1041.
Medication Comparisons
Compare medications used to treat Hirschsprung Disease Susceptibility To 9 C1968840. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy