Holoprosencephaly 1 C0266667
A severe brain malformation where the forebrain fails to divide into two halves. Present from birth, it often causes developmental delays and other serious health issues. Care focuses on managing symptoms and complications.
Key facts at a glance
- ICD-10
- Q04.2
- ICD-11
- LA00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Seizures
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Developmental delay
(neurologic)Facial anomalies
(neurologic)Hypothalamic dysfunction
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Seizure Management
Antiseizure medications are prescribed based on seizure type and EEG findings, with regular review and adjustment needed as seizures may evolve over time in patients with structural brain abnormalities.
Neurodevelopmental Monitoring
Regular assessments of cognitive development, motor skills, and functional abilities to guide educational planning, therapy services, and appropriate interventions.
Additional treatment options
Hydrocephalus Management
If hydrocephalus develops, surgical placement of ventriculoperitoneal shunt or endoscopic third ventriculostomy may be necessary to manage increased intracranial pressure.
surgicalRehabilitative Therapies
Comprehensive physical, occupational, and speech therapy services tailored to individual needs address motor deficits, feeding difficulties, and communication challenges.
physical_therapyNutritional Support
Assessment and management of nutritional needs, which may include specialized feeding techniques, dietary modifications, or tube feeding when oral intake is insufficient.
complementaryWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Holoprosencephaly 1 C0266667?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Holoprosencephaly 1 C0266667. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy