Holoprosencephaly 7 C1835820
A severe brain malformation associated with particular genetic factors. The forebrain fails to develop into two separate halves, causing profound health issues.
Key facts at a glance
- ICD-10
- Q04.2
- ICD-11
- LA00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Hydrocephalus
Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Midline facial anomalies
(neurologic)Intellectual disability
(neurologic)Ocular coloboma
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Craniofacial reconstruction surgery
Surgical procedures to address associated facial abnormalities including cleft lip/palate repair and skull reshaping to improve function and appearance.
Targeted drug therapy with dose adjustment
Active treatment with regular monitoring by a healthcare provider is recommended.
Neurodevelopmental surveillance program
Structured follow-up program including regular developmental assessments, brain imaging, and functional evaluations to guide treatment decisions.
Additional treatment options
Hormone replacement therapy
Treatment for pituitary hormone deficiencies including thyroid hormone, cortisol, and growth hormone replacement as indicated by laboratory testing.
medicationNeuropsychological support services
Psychological counseling and cognitive support for patients and families addressing developmental challenges, behavioral concerns, and family adjustment.
psychologicalGastrostomy tube placement
Surgical feeding tube placement for patients with significant feeding difficulties or aspiration risk ensuring adequate nutrition and hydration.
procedureWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Holoprosencephaly 7 C1835820?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Holoprosencephaly 7 C1835820. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy