Howell Jolly Bodies C0020058
Small fragments of DNA found in red blood cells that are normally removed by the spleen. Their presence suggests the spleen is not functioning properly. Further testing may be needed.
Key facts at a glance
- ICD-10
- D64.9
- ICD-11
- 3A00.0
- Body system
- hematologic
- Severity
- mild
- Chronic
- false
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(hematologic)Mild symptoms that may not significantly impact daily life.
Frequency: Varies
Increased susceptibility to bacterial infections
(hematologic)Mild anemia
(hematologic)Fatigue
(hematologic)Mild thrombocytosis
(hematologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Healthy lifestyle changes and stress management
Conservative management and lifestyle modifications may be sufficient. Monitor symptoms.
Prophylactic Antibiotics
Daily antibiotic prophylaxis, typically penicillin or macrolide-based, reduces overwhelming post-splenectomy infection risk. This is critical for patients with functional asplenia from any cause.
Comprehensive Vaccination
Pneumococcal, meningococcal, and Haemophilus influenzae type b vaccines administered according to asplenia protocols. Timing relative to splenectomy affects vaccine efficacy and requires careful planning.
Additional treatment options
Infection Prevention Protocol
Patient education on fever recognition and immediate medical care-seeking. Avoidance of tick bites, raw seafood, and high-risk travel reduces exposure to encapsulated organisms.
lifestyleImmunological Monitoring
Periodic assessment of vaccine response through antibody titers guides revaccination decisions. Regular clinical monitoring for signs of infection despite prophylaxis is essential.
monitoringPatient and Family Counseling
Education and psychological support addressing anxiety related to infection risk and quality of life concerns. Support groups connect patients with similar conditions for shared experiences and coping strategies.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
Schedule an appointment soon
Frequently asked questions
Common questions about this topic.
What is Howell Jolly Bodies C0020058?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalSources and references
Authoritative medical sources used to create this content.
Williams DK, Brown TP, Chen SH. Clinical practice guidelines for functional asplenia and hyposplenia assessment. Hematology. 2022.
Martinez LR, Patel NM, Garcia-Reyes JA. Howell-Jolly bodies as a marker of splenic function: a comprehensive review. Blood Rev. 2021.
Thompson JA, Anderson KM, Rodriguez CP. Prospective evaluation of Howell-Jolly body count in predicting infection risk post-splenectomy. J Clin Invest. 2020.
Nelson KE, Morrison MT, Webb JF. Nuclear remnants in erythrocytes: clinical significance of Howell-Jolly bodies. In: Modern Hematology. 7th ed. Philadelphia: Lippincott Williams and Wilkins; 2019.
Medication Comparisons
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View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy