Htra1 Disorder Cn381196
HTRA1 disorder is a genetic condition linked to the HTRA1 gene that can affect blood vessels and neurological function. It may cause small vessel disease and related symptoms. Care involves managing vascular and neurological complications.
Key facts at a glance
- ICD-10
- G40.909
- ICD-11
- 8A00.0
- Body system
- neurologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Warning signs - seek immediate care
Ischemic stroke
Visual impairment
Cognitive decline
(neurologic)Generalized symptoms
(neurologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Gait disturbance
(neurologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Antihypertensive therapy
Blood pressure control is essential in HTRA1-related cerebrovascular disease to reduce risk of stroke and slow disease progression. ACE inhibitors or ARBs may provide neurovascular protection beyond blood pressure control.
Medication management with follow-up
Active treatment with regular monitoring by a healthcare provider is recommended.
Regular neuroimaging surveillance
Periodic MRI imaging to monitor white matter changes, lacunar infarcts, and disease progression. Helps guide treatment decisions and assess intervention effectiveness.
Additional treatment options
Cardiovascular risk modification
Comprehensive approach including smoking cessation, regular exercise, and weight management to reduce vascular risk factors that compound HTRA1-related pathology.
lifestyleAntiplatelet therapy
Low-dose aspirin or other antiplatelet agents may be considered for secondary stroke prevention in HTRA1-related small vessel disease.
medicationNeuropsychological support
Cognitive assessment and support services address executive dysfunction and memory changes common in HTRA1 disorders. Provides coping strategies and family education.
psychologicalWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Htra1 Disorder Cn381196?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Htra1 Disorder Cn381196. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
If you think you may have a medical emergency, call your local emergency number or go to the nearest emergency department immediately.
Medically reviewed by WellAlly Editorial Team Last reviewed August 26, 2026. · Read our editorial policy