Hyper Igm Syndrome Type 5 C1720958
A genetic immune disorder impairing the body's ability to produce different antibody types. Patients experience repeated bacterial infections. Ongoing treatment with antibiotics and antibody therapy is typically needed.
Key facts at a glance
- ICD-10
- D89.9
- ICD-11
- 3A00.0
- Body system
- immunologic
- Severity
- severe
- Chronic
- true
Signs and symptoms
Common signs and symptoms that may indicate this condition.
Generalized symptoms
(immunologic)Significant symptoms that substantially affect daily functioning.
Frequency: Common at all stages
Recurrent bacterial infections
(immunologic)Chronic cryptosporidiosis
(immunologic)Autoimmune hemolytic anemia
(immunologic)Hepatobiliary carcinoma
(immunologic)Diagnosis and tests
How this condition is diagnosed and what test results mean.
Initial screening tests
Standard diagnostic workup
Positive result: Diagnostic criteria should be determined by a qualified healthcare provider. [Content pending medical review.]
Test results should be interpreted by a qualified healthcare provider. [Content pending medical review.]
Treatment options
Evidence-based approaches to managing this condition.
First-line treatments
Drug therapy and clinical monitoring
Active treatment with regular monitoring by a healthcare provider is recommended.
Immunoglobulin Replacement Therapy
Regular immunoglobulin replacement therapy to provide protective antibodies and reduce the frequency and severity of recurrent bacterial infections common in this UNG-dependent class-switching defect.
Aggressive Infection Management
Prompt initiation of broad-spectrum antibiotics at first sign of infection, with escalation based on culture results and clinical response, given the heightened susceptibility to bacterial pathogens.
Additional treatment options
Immunoglobulin Level Tracking
Serial measurement of serum immunoglobulin concentrations including IgG, IgA, and IgM to guide immunoglobulin replacement dosing and detect any changes in disease severity over time.
monitoringAbscess Drainage When Indicated
Surgical intervention for drainage of abscesses or collections that do not respond to antibiotic therapy alone, combined with appropriate antimicrobial coverage to prevent recurrence.
surgicalEnvironmental Pathogen Reduction
Comprehensive lifestyle modifications including improved indoor air quality, reduction of environmental allergens, and avoidance of known infectious exposures to minimize respiratory and systemic infection triggers.
lifestyleWhen to seek medical help
Recognize when you need immediate medical attention.
See a doctor within 24 hours
Moderate to severe symptoms that may indicate worsening of this condition. Prompt medical evaluation is recommended.
Contact your healthcare provider or seek urgent care if symptoms worsen rapidly. Go to the emergency department for life-threatening symptoms.
Frequently asked questions
Common questions about this topic.
What is Hyper Igm Syndrome Type 5 C1720958?
Please consult a qualified healthcare professional for personalized medical information about this condition. [Content pending medical review.]
generalMedication Comparisons
Compare medications used to treat Hyper Igm Syndrome Type 5 C1720958. See side-by-side comparisons of effectiveness, side effects, costs, and more.
View Medication ComparisonsThis information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment.
This content is for general informational and educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the guidance of a qualified healthcare provider with any questions you have about a medical condition, and never disregard professional medical advice or delay seeking it because of something you read here.
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Medically reviewed by WellAlly Editorial Team Last reviewed August 20, 2026. · Read our editorial policy